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PARS‑ECD® Kit

 Sterile, NonPyrogen Lyophilized Powder

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KIT FOR THE PREPARATION OF 99mTc (Sn)-Bicisate INJECTION
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SPECT Imaging
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Diagnostic
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About the Product

PARS‑ECD® is formulated for diagnostic use and helps physicians assess cerebral blood flow using SPECT imaging. The ECD kit is used for the preparation of 99mTc‑Bicisate. Imaging with this radiopharmaceutical provides precise information on cerebral perfusion.

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Applications
  • Diagnosis of cerebral blood flow abnormalities
  • Detection of cerebrovascular accident (CVA) / stroke
  • Evaluation of cerebrovascular diseases
  • Diagnosis of brain disorders such as tumors
  • Assessment of neurogenic disorders
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Mechanism of Action

Due to its N2S2 structure, Bicisate is a stable and lipophilic compound that readily crosses the blood–brain barrier. Once in the brain, it is converted into acidic metabolites, which cause it to become trapped and retained within brain tissue. Its uptake and distribution are directly dependent on cerebral blood flow; therefore, in areas affected by stroke or reduced perfusion, radiopharmaceutical accumulation is decreased.

99mTc‑Bicisate is selectively fixed in brain cells and, as it circulates through cerebral blood flow, can be detected using a gamma camera. This method helps physicians provide a more accurate diagnosis.

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Preparation and Administration

Note: This pharmaceutical product is intended solely for use in nuclear medicine facilities by personnel experienced in handling radiopharmaceuticals.

The PARS‑ECD kit is radiolabeled with sterile, non‑pyrogen sodium pertechnetate injection (Na⁹⁹ᵐTcO₄), eluted from a ⁹⁹Mo/⁹⁹ᵐTc generator, at the activity prescribed by the physician, and is then prepared for intravenous administration.

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Box Contents

Each box contains one instruction leaflet and four vials (two kit vials and two buffer solution vials), along with two labels specifically for the radiolabeling procedure.

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Composition

Ethyl Cysteinate Dimer (1 mg)

Stannous Chloride Dihydrate

Mannitol

EDTA

Phosphate Buffer Solution

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Storage Conditions
  • Store the PARS‑ECD kit in a refrigerator (2°C to 8°C) and protected from light. The cold chain must be maintained under all circumstances.
  • After radiolabeling, 99mTc‑Bicisate remains stable for up to 4 hours at 15°C to 25°C.
  • The ECD kit should not be used after the expiration date.
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